When a word begins with dis, you can usually remove dis and a root word will still exist (e.g. disappear = dis + appear).
When a word begins with des, it doesn't usually make sense if you remove the des (e.g. despise, describe).- The prefix in means 'not' before words beginning with most letters, except:
before a root word starting with l (in becomes il);
before a root word starting with m or p (in becomes im);
before a root word starting with r (in becomes ir).